منابع مشابه
The echinoderm adhesome.
Although the development of sea urchin embryos has been studied extensively and clearly involves both cell adhesion and cell migration, rather little is known about the adhesion receptors and extracellular matrix molecules involved. The completion of the genome of Strongylocentrotus purpuratus allows a comprehensive survey of the complement of cell-cell and cell-matrix adhesion molecules in thi...
متن کاملThe switchable integrin adhesome.
Adhesion sites, which interconnect cells with their neighbors or with the extracellular matrix (ECM), are large multiprotein complexes that provide mechanical coupling as well as a means for cells to sense the chemical and physical properties of their environment (Bershadsky et al., 2003; Chen et al., 2004; Geiger et al., 2001; Sastry and Burridge, 2000). The complex interplay between the mecha...
متن کاملEvolution of complexity in the integrin adhesome
Integrin-mediated adhesion is as ancient as multicellularity, but it was not always as complex as it is in humans. Here, I examine the extent of conservation of 192 adhesome proteins across the genomes of nine model organisms spanning one and a half billion years of evolution. The work reveals that Rho GTPases, lipid- and serine/threonine-kinases, and phosphatases existed before integrins, but ...
متن کاملThe integrin adhesome network at a glance
The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks. The connection between integrins and the cytoskeleton is mediated by a dynamic integrin adhesion complex (IAC), the components of which transduce chemical and mechanical signals to control a multitude of cellular functions. In this Cell Science at a Glance article and ...
متن کاملCadherin adhesome at a glance.
This article is part of a Minifocus on Adhesion. For further reading, please see related articles: ‘Cycling around cell–cell adhesion with Rho GTPase regulators’ by Jessica McCormack et al. (J. Cell Sci. 126, 379391). ‘E-cadherin–integrin crosstalk in cancer invasion and metastasis’ by Marta Canel et al. (J. Cell Sci. 126, 393-401). ‘Mechanosensitive systems at the cadherin– F-actin interface’ ...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2006
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2006.07.044